| Factor Information | |
|---|---|
| Data ID | 3575 |
| Factor | PST (cardiac parasympathetic nervous tone) (bpm) |
| Description | In Fontan patients, the lower β sensitivity of the sinus node and the PST mainly determined the higher cNCR ( p<0.01) and the cNCR did not correlate with either hemodynamics or exercise capacity. |
| Biomarker | NA |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | treatment and prognosis |
| Objective | To investigate the negative chronotropic response (NCR) to low-dose atropine in postoperative patients with congenital heart disease (CHD). |
| p Value | <0.001 |
| Conclusion | PST and cPST were also lower in the CHD groups, especially in the complex and Fontan patients and were proportionally decreased according to the exercise capacity. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 557 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/other |
| Reference | |
|---|---|
| PMID | 15771928 |
| Year | 2005 |
| Title | Negative chronotropic response to low-dose atropine is associated with parasympathetic nerve-mediated cardiovascular response in postoperative patients with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | All (9-36 years) | |
| Source | patients | |
| Region | Osaka, Japan | |
| Method | NCR corrected for basal heart rate (HR) (minimal HR/basal HR=cNCR) was determined after low-dose atropine (3 Ag/kg) administration and was compared with the cardiac autonomic nervous and functional status. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Fontan(Treatment) | AVSD(Control) |
| Number | 27 | 17 |
| Age | 14.4±5.8 years | 15.1±4.6 years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 12±11 bpm | 50±14 bpm |
