| Factor Information | |
|---|---|
| Data ID | 3625 |
| Factor | Heart rate (Delta-HRp) |
| Description | In the complex CHD patients, higher cNCR was mainly associated with the lower pharmacologically determined cardiac parasympathetic nervous tone (PST), HR variability, high atrial natriuretic peptide, and lower right ventricular ejection fraction ( p<0.0001). |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | treatment and prognosis |
| Objective | To investigate the negative chronotropic response (NCR) to low-dose atropine in postoperative patients with congenital heart disease (CHD). |
| p Value | <0.01 |
| Conclusion | NCR is attenuated in proportion to the impaired cardiac parasympathetic nervous system and hemodynamics in postoperative complex biventricular CHD patients. In addition to PST, β sensitivity of the sinus node significantly influences the NCR in Fontan patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 557 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/other |
| Reference | |
|---|---|
| PMID | 15771928 |
| Year | 2005 |
| Title | Negative chronotropic response to low-dose atropine is associated with parasympathetic nerve-mediated cardiovascular response in postoperative patients with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | All (9-36 years) | |
| Source | patients | |
| Region | Osaka, Japan | |
| Method | NCR corrected for basal heart rate (HR) (minimal HR/basal HR=cNCR) was determined after low-dose atropine (3 Ag/kg) administration and was compared with the cardiac autonomic nervous and functional status. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Complex CHD(Treatment) | AVSD(Control) |
| Number | 80 | 17 |
| Age | 15.5±5 years | 15.1±4.6 years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 88±19 bpm | 102±11 bpm |
