| Factor Information | |
|---|---|
| Data ID | 3683 |
| Factor | endothelin-1(ET-1) |
| Description | On the 7th day after operation, plasma ADM and ET-1 levels in PH group were significantly decreased (P<0.05, P<0.01) as compared with those before operation, but there was no significant difference in NO levels (P>0. 05). |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | The changes of ADM, ET-l and NO levels before and after operation in CHD associated with PH were observed in Order to investigate their role in CHD with PH and their clinical significance. |
| p Value | <0.05 |
| Conclusion | It was concluded that during the progression of PH in the cases of CHD, plasma ADM, ET-1 and NO might play an important role in the development of PH. The increased ADM may represent a compensatory mechanism. It can interact with NO and ET-1 to regulate pulmonary circulation in the pathophysiology of PH with CHD. ADM may be involved in the defence mechanism against further increase of pulmonary arterial pressure. ADM could be used as a reliable indicator of the severity of CHD associated PH. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 390 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/PDA |
| Reference | |
|---|---|
| PMID | 14526432 |
| Year | 2003 |
| Title | Role of adrenomedullin in congenital heart disease associated with pulmonary hypertension. |
| Sample | ||
|---|---|---|
| Population | Children | |
| Source | Plasma | |
| Region | Wuhan, China | |
| Method | radioimmunoassay and colorimetry methods. | |
| Race | Asian | |
| Disease History | pulmonary hypertension | |
| Treatment History | N/A | |
| Group | postoperation in PH (Pulmonary Hypertension)(Treatment) | preoperation in PH (Pulmonary Hypertension)(Control) |
| Number | 16 | 16 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 92.42±30.5 pg/mL | 113.64±38.45 pg/mL |
