| Factor Information | |
|---|---|
| Data ID | 3737 |
| Factor | Myocardial β2-receptor gene expression |
| Description | Myocardial β1- and β2-receptor gene expression in 16 children who received standard treatment for heart failure with digoxin and diuretics averaged lower than in the 10 children who received additional propranolol (β1-receptor: p=0.37; β2-receptor 0.08 ±0.05 versus 0.12±0.05, p =0.043). |
| Biomarker | NA |
| Classification | D2 (molecular factor - gene expression) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | β-Receptor Downregulation in Congenital Heart Disease: A Risk Factor for Complications After Surgical Repair? |
| p Value | 0.043 |
| Conclusion | β-Receptor downregulation due to congestive heart failure has an impact on the postoperative course in children with congenital disease and depends on heart failure therapy. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 696 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | AVSD/VSD/PA/RV-PA-Cd/TOF/PI/DILV/L-TGA/PAB/TA/AP window/DILV, L-TGA/DORV, SPS/MA/AVSD, CoA, PAB/TA, CoA, PAB |
| Reference | |
|---|---|
| PMID | 11845882 |
| Year | 2002 |
| Title | Beta-receptor downregulation in congenital heart disease: a risk factor for complications after surgical repair? |
| Sample | ||
|---|---|---|
| Population | All | |
| Source | right atrium during cardiac surgery | |
| Region | Gottingen, Germany | |
| Method | Myocardial biopsies/real-time polymerase chain reaction with fluorescence- labeled products | |
| Race | European | |
| Disease History | N/A | |
| Treatment History | Biventricular repair/Glenn op/TCPC/PAB/DKS/CoA resection | |
| Group | 16 children who received standard treatment for heart failure with digoxin and diuretics averaged(Treatment) | 10 children who received additional propranolol(Control) |
| Number | 16 | 10 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 0.08 ±0.05 | 0.12±0.05 |
