CHDRFKB

Factor Information
Data ID	3754
Factor	Comparison of proportion of first Cousins in CHD
Description	Table I compares the difference in the proportion of first-cousin consanguinity in the study sample with that in the general population (P < .001) and demonstrates that the proportion of first-cousin marriages is significantly higher in the CHD group than in the general population (P < .001).
Biomarker	NA
Classification	A8 (clinical factor - relationship)

Association
Application	risk assessment
Objective	Relationship between Consanguinity and Congenital Heart Disease
p Value	<0.001
Conclusion	Data from this study suggest a multifactorial pattern of inheritance of some, but not all, heart malformations, particularly VSD, ASD, and AVSD. When relatives intermarry, there is a general increase in homozygosity which may explain the signicantly higher rates of consanguinity in the study sample for some subgroups of CHD. This suggests a recessive component for ASD, VSD, PA, PS, and AVSD defects. TOF, TA, AS, and CoA may have different modes of inheritance, or they may be sporadic events.
Risk Factor	unknown

CHD Type
ID	701
CHD Type	isolated CHD
CHD Subtype	TOF/AVSD/D-TGA/TA/PA/MA/PS/AS/CoA/VSD/ASD/PDA/EA/other

Reference
PMID	11170087
Year	2001
Title	Consanguinity and congenital heart disease in Saudi Arabia.