| Factor Information | |
|---|---|
| Data ID | 3755 |
| Factor | Proportion of AVSD with first cousins |
| Description | N/A |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | Relationship between Consanguinity and Congenital Heart Disease |
| p Value | <0.01 |
| Conclusion | data from this study suggest a multifactorial pattern of inheritance of some, but not all, heart malformations, particularly VSD, ASD, and AVSD. When relatives intermarry, there is a general increase in homozygosity which may explain the signi®cantly higher rates of consanguinity in the study sample for some subgroups of CHD. This suggests a recessive component for ASD, VSD, PA, PS, and AVSD defects. TOF, TA, AS, and CoA may have different modes of inheritance, or they may be sporadic events. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 20 |
| CHD Type | isolated CHD |
| CHD Subtype | AVSD |
| Reference | |
|---|---|
| PMID | 11170087 |
| Year | 2001 |
| Title | Consanguinity and congenital heart disease in Saudi Arabia. |
| Sample | ||
|---|---|---|
| Population | All | |
| Source | N/A | |
| Region | Riyadh, Saudi Arabia | |
| Method | N/A | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | First Cousins(Treatment) | N/A(Control) |
| Number | 44 | N/A |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 0.45 | N/A |
