| Factor Information | |
|---|---|
| Data ID | 394 |
| Factor | VE/VCO2 slope |
| Description | Risk prediction using cardiopulmonary exercise testing (CPET) in complex congenital heart disease tends to either focus on single diagnoses or complete cohorts. |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | evaluate patients with two distinct anatomies cared for at a single institution over the same time period to determine CPET variables associated with mortality. |
| p Value | 0.002 |
| Conclusion | Variables most predictive of mortality in Fontan and TOF patients diverge but spirometry was abnormal and associated with mortality in both groups. When compared with age-matched controls, reduced FEV1 and FVC correlated most strongly with mortality for TOF patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 53 |
| CHD Type | isolated CHD |
| CHD Subtype | TOF |
| Reference | |
|---|---|
| PMID | 30216689 |
| Year | 2018 |
| Title | Exercise testing and spirometry as predictors of mortality in congenital heart disease: Contrasting Fontan physiology with repaired tetralogy of Fallot. |
| Sample | ||
|---|---|---|
| Population | Adults | |
| Source | a retrospective study | |
| Region | Boston, USA | |
| Method | reviewed | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | TOF index cases(Treatment) | TOF control cases(Control) |
| Number | 15 (TOF cases) | 45 (TOF controls) |
| Age | 42.0 ± 15.3 years | 41.6 ± 14.6 years |
| Gender (Male: Female) | 9:6 | 24:21 |
| Marker Level | 33.9 ± 12.9 | 26.6 ± 4.4 |
