| Factor Information | |
|---|---|
| Data ID | 3967 |
| Factor | clinical index of neurodevelopment |
| Description | RED and BLACK refer to the clustered classification of patients obtained by the principal component analysis of metabolomic urinary NMR spectra |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To evaluate whether the metabolic clustering show a good prognostic performance on neurodevelopmental outcome. |
| p Value | 0.01 |
| Conclusion | Metabolic profiles belonging to the RED cluster showed higher levels of accumulation of citric acid cycle intermediates and glucose compared to the profiles in the BLACK cluster, indicating a possible switching to anaerobic metabolism. Patients belonging to the RED cluster were significantly more prone to show an adverse neurodevelopment pattern . |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 738 |
| CHD Type | isolated CHD |
| CHD Subtype | TGA/TOF/SD/UVH |
| Reference | |
|---|---|
| PMID | 31667397 |
| Year | 2019 |
| Title | Pre-surgery urine metabolomics may predict late neurodevelopmental outcome in children with congenital heart |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients | |
| Region | Padova, Italy | |
| Method | principal component analysis of metabolomic urinary NMR spectra | |
| Race | Eupopean | |
| Disease History | N/A | |
| Treatment History | cardiac surgery operation | |
| Group | metabolic cluster of black, with impaired(Treatment) | metabolic cluster of red, normal(Control) |
| Number | 5 | 1 |
| Age | < 5 years | < 5 years |
| Gender (Male: Female) | 1:1(total) | 1:1(total) |
| Marker Level | 0.714 | 0.083 |
