| Factor Information | |
|---|---|
| Data ID | 3972 |
| Factor | relative levels of expression of miRNA-208a |
| Description | The relative levels of expression of miRNA-208a were 3.7 times higher in the group of children with an uncomplicated postoperative course. |
| Biomarker | YES |
| Classification | D2 (molecular factor - gene expression) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To access an association between the preoperative levels of miRNA208a and the risk of developing complications. |
| p Value | 0.03 |
| OR | 1.16 |
| Conclusion | The relative levels of expression of miRNA-208a were significantly higher in the group of children with an uncomplicated postoperative course than those with complications. The lower the level of miRNA-208a in the patient’s blood before the operation, the higher was the risk for developing complications following surgery(also after adjusting for the child’s age and Aristotle score). |
| Risk Factor | no influencing factor(unadjusted) |
| CHD Type | |
|---|---|
| ID | 739 |
| CHD Type | NA |
| CHD Subtype | VSD, ASD/AVC/TGA/TOF/CoA/RV to PAC |
| Reference | |
|---|---|
| PMID | 31732917 |
| Year | 2019 |
| Title | Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients blood | |
| Region | Tel-Aviv, Israel | |
| Method | RT-PCR | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | cardiac surgery | |
| Group | CHD with complications(Treatment) | CHD without complications(Control) |
| Number | 26 | 53 |
| Age | 6.8 (0.4–33.9) months | 6.8 (0.4–33.9) months |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | <1 | 3.7 times higher of the group with complications |
