| Factor Information | |
|---|---|
| Data ID | 3973 |
| Factor | relative average miRNA-208 expression in children with oxygen saturation below 90% |
| Description | The relative levels of expression of miRNA-208a before surgery among the children with oxygen saturation levels below 90% (n = 38) were 9.0 times higher for those without postoperative cardiac complications compared with the children who did sustain them (p = 0.01). |
| Biomarker | YES |
| Classification | D2 (molecular factor - gene expression) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To access if the group of patients with oxygen saturation levels below 90% yield a statistically significant association between the preoperative level of miRNA-208a and the risk of developing postoperative complications. |
| p Value | 0.03 |
| OR | 1.27 |
| Conclusion | The lower the level of miRNA-208a in the patient’s blood before the operation, the higher was the risk for developing cardiac complications following surgery(also after adjusting for the child’s age and Aristotle score). |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 739 |
| CHD Type | NA |
| CHD Subtype | VSD, ASD/AVC/TGA/TOF/CoA/RV to PAC |
| Reference | |
|---|---|
| PMID | 31732917 |
| Year | 2019 |
| Title | Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients blood | |
| Region | Tel-Aviv, Israel | |
| Method | RT-PCR | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | cardiac surgery | |
| Group | CHD with complications of oxygen saturation below 90%(Treatment) | CHD without complications of oxygen saturation below 90%(Control) |
| Number | 16 | 22 |
| Age | 3.6 (0.2–17.0) months | 3.6 (0.2–17.0) months |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | <2 | 9 times higher of the group with complications |
