| Factor Information | |
|---|---|
| Data ID | 4 |
| Factor | CK |
| Description | LDH, CK, CK‐MB were significantly higher than that in controls. |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To access novel diagnostic biomarkers for congenital heart disease in children |
| p Value | <0.05 |
| Conclusion | identified three circRNAs(LDH, CK, CK‐MB) under‐expressed in plasma from children with CHD. These circRNAs may be crucial in the development of CHD and may serve as novel non‐invasive biomarkers for the diagnosis of CHD in children. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 38 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD |
| Reference | |
|---|---|
| PMID | 31429492 |
| Year | 2019 |
| Title | Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | plasma | |
| Region | Nanjing, China | |
| Method | Gene ontology (GO), pathway, and network analysis were performed to predict a network of circRNA/miRNA and target mRNAs related to CHD. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | VSD/ASD(Treatment) | healthy children(Control) |
| Number | 40 | 40 |
| Age | N/A | matched with cases on the basis of age and gender |
| Gender (Male: Female) | F/M | F/M |
| Marker Level | 167.65 ± 162.46 (U/L) | 89.83 ± 38.97 (U/L) |
