| Factor Information | |
|---|---|
| Data ID | 4019 |
| Factor | NLRP3(nucleotide-binding oligomerization domain-like (NOD)-like receptor protein 3) |
| Description | To access the relationship between plasma levels of nucleotide-binding oligomerization domain-like (NOD)-like receptor protein 3 (NLRP3) and high-mobility group box 1 (HMGB1) and 2-year mortality in neonatal patients with CHD. |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To investigate the association between plasma levels of NLRP3 and HMGB1 and their prognostic significance in neonatal patients with CHD. |
| p Value | 0.003 |
| OR | 2.159 |
| Conclusion | Multivariate analysis demonstrated that plasma NLRP3 (odds ratio [OR] 2.159, 95% confidence interval [CI] 1.309, 3.561; P=0.003) and HMGB1 (OR 2.726, 95% CI 1.221, 6.038; P=0.014) were both independent risk factors for 2-year mortality. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 31852352 |
| Year | 2019 |
| Title | NOD-like receptor protein 3 and high mobility group box-are associated with prognosis of patients with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients | |
| Region | Hangzhou, China | |
| Method | To access the relationship between plasma levels of nucleotide-binding oligomerization domain-like (NOD)-like receptor protein 3 (NLRP3) and high-mobility group box 1 (HMGB1) and 2-year mortality in neonatal patients with | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | neonatal patients with CHD(Treatment) | N/A(Control) |
| Number | N/A | N/A |
| Age | < 3 years old | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A( 2-year mortality) | N/A |
