| Factor Information | |
|---|---|
| Data ID | 4052 |
| Factor | relative miR-204 expression in severe group |
| Description | The plasma miR-204 expression was lower after surgery than before surgery in the mild PH group (P<0.05) and in the severe PH group (P<0.01). |
| Biomarker | YES |
| Classification | D2 (molecular factor - gene expression) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To compare the plasma miR-204 expression in the different process of surgery in severe PH group. |
| p Value | <0.01 |
| Conclusion | One hour before surgery and 7 days after surgery, plasma miR-204 expression was at a higher level than that in the mild PH group and higher than in the severe PH group. miR-204 expression in children in each group showed a decreasing trend after surgery. The mild PH and severe PH groups had lower plasma miR-204 expression and PASP after surgery than before surgery. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 747 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | VSD/ASD/VSD, ASD/PDA/VSD, PDA/ASD, PDA |
| Reference | |
|---|---|
| PMID | 31887731 |
| Year | 2020 |
| Title | MicroRNA-204 as an Indicator of Severity of Pulmonary Hypertension in Children with Congenital Heart Disease Complicated with Pulmonary Hypertension |
| Sample | ||
|---|---|---|
| Population | infants/children | |
| Source | blood samples | |
| Region | Guizhou, China | |
| Method | RT-PCR | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | treated with conventional corrective sur- gery, combined intravenous and inhalation anesthesia, and cardiopulmonary bypass (CPB) and equipment | |
| Group | severe PH group pre-operation(Treatment) | severe PH group post-operation(Control) |
| Number | 21 | 21 |
| Age | 5.500±2.060 years | 5.500±2.060 years |
| Gender (Male: Female) | 8:13 | 8:13 |
| Marker Level | N/A | N/A |
