| Factor Information | |
|---|---|
| Data ID | 4075 |
| Factor | volumns of cerebellum(CBL) |
| Description | Associations between PSS(Perceived Stress Scale) and fetal brain volumn. For controls, β denotes the association for a 1-unit increase in maternal psychological distress scale and fetal brain volume in the control group with 95% CIs around the estimate |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | To determine the association of maternal psychological distress with brain development in fetuses with CHD. |
| p Value | 0.02 |
| Conclusion | The cerebellum was differentially associated with maternal trait anxiety and stress in CHD vs controls and with maternal trait anxiety and stress negatively associated with cerebellum volumes in fetuses with CHD. It suggested that psychological distress among women carrying fetuses with CHD is prevalent and is associated with impaired fetal cerebellar and hippocampal development. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 31930365 |
| Year | 2020 |
| Title | Association of Maternal Psychological Distress With In Utero Brain Development in Fetuses With Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | fetus and their mothers | |
| Source | fetus brain, maternal psychological distress | |
| Region | Washington, USA | |
| Method | Maternal psychological distress was measured using psycho- metrically sound questionnaires, namely, the Perceived Stress Scale (PSS),20 Edinburgh Postnatal Depression Scale (EPDS),21 and Spielberger State-Trait Anxiety Inventory (SSAI, state anxiety; STAI, trait anxiety). CBL was measured by MRI. | |
| Race | American | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Significant association after adjusting for multiple testing(Treatment) | controls(Control) |
| Number | 48 | 92 |
| Age | 32.7 (5.5) [18.8-43.3] years | 33.7 (5.4) [20.4-48.5] years |
| Gender (Male: Female) | 28:20 | 49:43 |
| Marker Level | PSS:β (95% CI)=-0.06cm3(-0.09 to -0.02) | PSS:β (95% CI)=0.01(-0.03 to 0.05) |
