| Factor Information | |
|---|---|
| Data ID | 4199 |
| Factor | with 1 or 2+ variants in PRA gene |
| Description | NA |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the impact of damaging genetic variation in proangiogenic pathways on placental function, complications of pregnancy, fetal growth, and clinical outcomes in pregnancies with CHD. |
| p Value | 0.049 |
| Conclusion | The presence of a damaging PRA variant was also associated with lower neonatal length and head circumference for age z score at birth (mean 0.44 and 0.47 with variant vs 0.23 and 0.05 without; P = .01 and .04, respectively |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 752 |
| CHD Type | isolated CHD |
| CHD Subtype | HLHS/IAA/TGA/TOF/other |
| Reference | |
|---|---|
| PMID | 31227283 |
| Year | 2019 |
| Title | Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients | |
| Region | Philadelphia, USA | |
| Method | Exome sequencing, GeneVetter analysis | |
| Race | American | |
| Disease History | NA | |
| Treatment History | surgical repair | |
| Group | with suspect genetic anomaly(Treatment) | with genetic anomaly of 0 variants(Control) |
| Number | 13 | 50 |
| Age | NA | NA |
| Gender (Male: Female) | 41:32 | 40:20 |
| Marker Level | 0.178 | 0.685 |
