| Factor Information | |
|---|---|
| Data ID | 4204 |
| Factor | birth head circumference |
| Description | P value for a comparison of variant 0 vs 1 or 2+ from x2 test or Fisher exact test for categorical variables and Wilcoxon rank-sum test or 2-sample t test for continuous variables |
| Biomarker | NA |
| Classification | E14 (physiological factor - birth head circumference) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the impact of damaging genetic variation in proangiogenic pathways on placental function, complications of pregnancy, fetal growth, and clinical outcomes in pregnancies with CHD. |
| p Value | 0.02 |
| Conclusion | The presence of a damaging PRA variant was also associated with lower neonatal length and head circumference for age z score at birth (mean 0.44 and 0.47 with variant vs 0.23 and 0.05 without; P = .01 and .04, respectively |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 752 |
| CHD Type | isolated CHD |
| CHD Subtype | HLHS/IAA/TGA/TOF/other |
| Reference | |
|---|---|
| PMID | 31227283 |
| Year | 2019 |
| Title | Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients | |
| Region | Philadelphia, USA | |
| Method | Exome sequencing, GeneVetter analysis | |
| Race | American | |
| Disease History | NA | |
| Treatment History | surgical repair | |
| Group | with genetic anomaly of 1 or 2+ variants(Treatment) | with genetic anomaly of 0 variants(Control) |
| Number | 73 | 60 |
| Age | NA | NA |
| Gender (Male: Female) | 41:32 | 40:20 |
| Marker Level | 33.4 ± 1.6cm | 34.1 ± 1.6cm |
