| Factor Information | |
|---|---|
| Data ID | 4214 |
| Factor | Factors associated with Head circumference z score: PRA gene variatnts |
| Description | unadjusted |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the impact of damaging genetic variation in proangiogenic pathways on placental function, complications of pregnancy, fetal growth, and clinical outcomes in pregnancies with CHD. |
| p Value | 0.04 |
| Conclusion | The presence of at least 1damaging PRA variant was also associated with lower birth head circumference z score in both univariate and multivariable analyses. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 752 |
| CHD Type | isolated CHD |
| CHD Subtype | HLHS/IAA/TGA/TOF/other |
| Reference | |
|---|---|
| PMID | 31227283 |
| Year | 2019 |
| Title | Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients | |
| Region | Philadelphia, USA | |
| Method | univariate analysis | |
| Race | American | |
| Disease History | NA | |
| Treatment History | surgical repair | |
| Group | with PRA gene variants of 1 or 2+ (Treatment) | without PRA gene variants(Control) |
| Number | 50 | 50 |
| Age | NA | NA |
| Gender (Male: Female) | NA | NA |
| Marker Level | -0.47 ± 1.12 | -0.05 ± 1.20 |
