| Factor Information | |
|---|---|
| Data ID | 4221 |
| Factor | Factors associated with UA-PI z score: PRA gene variatnts |
| Description | unadjusted |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the impact of clinical variables on placental function, complications of pregnancy, fetal growth, and clinical outcomes in pregnancies with CHD. |
| p Value | 0.03 |
| Conclusion | The presence of a damaging PRA variant in the fetus was associated with an increased UA-PI z score (mean 1.2 with PRA variant vs 0.62 without; P = .03). |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 752 |
| CHD Type | isolated CHD |
| CHD Subtype | HLHS/IAA/TGA/TOF/other |
| Reference | |
|---|---|
| PMID | 31227283 |
| Year | 2019 |
| Title | Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients | |
| Region | Philadelphia, USA | |
| Method | univariate analysis | |
| Race | American | |
| Disease History | NA | |
| Treatment History | surgical repair | |
| Group | with PRA gene variants of 1 or 2+ (Treatment) | without PRA gene variants(Control) |
| Number | 41 | 92 |
| Age | NA | NA |
| Gender (Male: Female) | NA | NA |
| Marker Level | 1.20 ± 1.25 | 0.62 ± 1.42 |
