| Factor Information | |
|---|---|
| Data ID | 4233 |
| Factor | Relation between Maternal vitamin D status and VDR gene Fok1 polymorphism among cases: Defieient |
| Description | NA |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | To access the association between maternal vatimin D status in relation to Fok1 polymorphism genotype and the offsrping of CHD. |
| Conclusion | A significant decrease on serum vitamin D (P=0.000) and deficient vitamin D status(P=0.000) were observed in maternal cases who carrying f/f genotype followed by F/f genotype when compared to F/F wild genotype. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 753 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/PDA/TGA/TOF/TAS/HLHS/DORV |
| Reference | |
|---|---|
| PMID | 31194013 |
| Year | 2018 |
| Title | Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | Peripheral blood of patients | |
| Region | Zagazig, Egypt | |
| Method | ELISA, RFLP PCR assay | |
| Race | African | |
| Disease History | Previous CHD in sibilings with 20% of cases and 4% in controls | |
| Treatment History | NA | |
| Group | maternal Fok1 genotype: f/f(Treatment) | maternal Fok1 genotype: F/F(Control) |
| Number | 6 | 2 |
| Age | 28(20-35) years | 28(20-35) years |
| Gender (Male: Female) | 00:06:00.000 | 00:02:00.000 |
| Marker Level | 0.25 | 0.083 |
