| Factor Information | |
|---|---|
| Data ID | 495 |
| Factor | frequencies of MTHFR gene 677 TT genotype in the mothers |
| Description | The frequency of the MTHFR gene 677 TT polymorphism in the mothers who had offspring with TOF was significantly higher than that in the non-CHD controls (P<0.05). |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | offspring CHD risk |
| p Value | 0.0033 |
| OR | 2.93 |
| Conclusion | A significant interaction was found between the homozygous 677 T/T MTHFR gene in children and the maternal occupational status and level of drug exposure during gestation. Avoiding or reducing the exposure of the risk factors mentioned above, strengthening pre-pregnancy checkups and guidance might help to reduce the risk of CHD |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 53 |
| CHD Type | isolated CHD |
| CHD Subtype | TOF |
| Reference | |
|---|---|
| PMID | 29600076 |
| Year | 2018 |
| Title | Risk factors and methylenetetrahydrofolate reductase gene in congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | mothers | |
| Source | interview | |
| Region | Beijing, China | |
| Method | The MTHFR genotype was analyzed by RFLP.Interactions between environmental risk factors and MTHFR gene polymorphisms were evaluated by the RERI, the attributable proportion due to interaction (AP), and the synergy index (S). | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | the mothers who had offspring with TOF(Treatment) | the mother of the children with non-CHD(Control) |
| Number | 18(total:41) | 50(total:237) |
| Age | ≤20 years 20 (5.8%); 21–34 years 254 (73.4%); ≥35 years 72 (20.8). | ≤20 years 12 (5.1%); 21–34 years 182 (76.8%); ≥35 72 years 43 (18.1%) |
| Gender (Male: Female) | 0:18 | 0:50 |
| Marker Level | 0.439 | 0.211 |
