| Factor Information | |
|---|---|
| Data ID | 498 |
| Factor | Genotypes of SNP rs2243890 A>G in RCAN1.4 promoter region |
| Description | we combined the data from both cohorts for combined analysis and the result showed that the distribution of the minor G allele of rs2243890 was significantly different between the CHD and control groups. The CHD risk was significantly increased by 1.66-fold due to the G allele (OR = 1.66, 95% CI= 1.30ā2.11, P = 4.68Eā05) |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | To access the correlation between the polymorphism of RCAN1.4 and CHD risk. |
| p Value | <0.0001 |
| OR | 1.76 |
| Conclusion | The result showed that the distribution of the minor G allele of rs2243890 was significantly different between the CHD and control groups. The CHD risk was significantly increased by 1.66-fold due to the G allele (OR = 1.66, 95% CI= 1.30ā2.11, P = 4.68Eā05) |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 29594719 |
| Year | 2019 |
| Title | Decreased activity of RCAN1.4 is a potential risk factor for congenital heart disease in a Han Chinese population |
| Sample | ||
|---|---|---|
| Population | N/A | |
| Source | blood | |
| Region | Shandong, China | |
| Method | target-capture sequencing | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD cases(Treatment) | controls(Control) |
| Number | 41/159/707(AA/AG/GG) | 71/149/1164(AA/AG/GG) |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 41/159/707(AA/AG/GG) | 71/149/1164(AA/AG/GG) |
