| Factor Information | |
|---|---|
| Data ID | 511 |
| Factor | brain stem(BS) |
| Description | Children with a below-average Fulll-scale IQ (<85, n=9) showed smaller volumes of basal ganglia thalami (-8%, p=0.03) and brain stem (BS) (-7%, p=0.03). |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | smaller volumes of brain stem |
| p Value | 0.03 |
| Conclusion | provide evidence of unfavourable outcome in school-age children with critical CHD who acquire perioperative neonatal brain injury. |
| Risk Factor | protective factor |
| CHD Type | |
|---|---|
| ID | 463 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | SV/HLHS/Taussig–Bing anomaly/IAA, HAA/CoA, HAA |
| Reference | |
|---|---|
| PMID | 29572821 |
| Year | 2018 |
| Title | Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | Brain | |
| Region | Utrecht, Netherlands | |
| Method | cerebral magnetic resonance imaging; neurodevelopment was assessed at 24 months & 6 years, Brain injury, brain volumes, and cortical measures | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | neonatal cardiac surgery | |
| Group | Children with a below-average Fulll-scale IQ (<85)(Treatment) | Children with a below-average Fulll-scale IQ (>85)(Control) |
| Number | 9 | 21 |
| Age | Median (IQR) gestational age: 39.1 (38.7–40.0) wks | Median (IQR) gestational age: 39.1 (38.7–40.0) wks |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 6.9 (0.4)ml | 7.4 (0.5)ml |
