| Factor Information | |
|---|---|
| Data ID | 512 |
| Factor | T‑box transcription factor 1 (TBX1) expression |
| Description | The results revealed that 10 fetuses had CHD (1%), of which ultrasound detected 9 cases. The specificity and sensitivity of ultrasounds were 100 and 90%, respectively. PCR and western blotting demonstrated that TBX1 expression may be associated with CHD. |
| Biomarker | YES |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | diagnosis |
| Objective | PCR and western blotting demonstrated that TBX1 expression may be associated with CHD |
| p Value | <0.05 |
| Conclusion | PCR and western blotting demonstrated that TBX1 expression may be associated with CHD, These methods may be significant to improve the rate of CHD diagnosis, and require further investigation. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 464 |
| CHD Type | isolated CHD |
| CHD Subtype | Triatial heart/EA/SV/VSD/TOF/PS/ECD |
| Reference | |
|---|---|
| PMID | 29568912 |
| Year | 2018 |
| Title | Clinical study of prenatal ultrasonography combined with T-box transcription factor 1 as a biomarker for the diagnosis of congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | pregnant women | |
| Source | Blood | |
| Region | Jining, China | |
| Method | ultrasonography, molecular biology methods [Polymerase chain reaction (PCR) and western blotting] | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD cases(Treatment) | controls(Control) |
| Number | 10 | 990 |
| Age | 18‑30 years | 18‑30 years |
| Gender (Male: Female) | 0:10 | 0:990 |
| Marker Level | mean value:<25% | mean value:>75% |
