| Factor Information | |
|---|---|
| Data ID | 523 |
| Factor | percent predicted forced expiratory volume in 1 s(FEV1) |
| Description | Inverse correlations were shown for CHD-APAH between medical research council dyspnea score and percent predicted forced expiratory volume in 1 s (r=-0.6662, P=0.0018) |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | medical research council dyspnea score (Inverse correlations) |
| p Value | <0.01 |
| Conclusion | Raised biomarkers for inflammation were found in CHD-APAH. Significant abnormalities in airway physiology may contribute to the dyspnea but are not driven by inflammation as assessed by circulating and sputum cytokines. A relationship between increased serum endothelin-1 and airway dysfunction may relate to its bronchoconstrictive properties. |
| Risk Factor | unrelated |
| CHD Type | |
|---|---|
| ID | 466 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/TGA/DILV/TA/TOF/PS/TA/EA |
| Reference | |
|---|---|
| PMID | 29444773 |
| Year | 2018 |
| Title | Lung Function, Inflammation, and Endothelin-1 in Congenital Heart Disease-Associated Pulmonary Arterial Hypertension. |
| Sample | ||
|---|---|---|
| Population | Adults | |
| Source | blood and induced sputum | |
| Region | Bristol, United Kingdom | |
| Method | Spirometry, gas transfer, whole body plethysmography and lung clearance index | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | Surgical Operation | |
| Group | CHD-PAH(Treatment) | healthy volunteers(Control) |
| Number | 20 | 18 |
| Age | Median age (IQR): 42.7 (33.1–57.7) years | N/A |
| Gender (Male: Female) | 8:12 | N/A |
| Marker Level | 70.7 (58.5–81.8)( | 99.1 (92.9–105.0) |
