| Factor Information | |
|---|---|
| Data ID | 527 |
| Factor | breathless with lower 6-minute walk distance |
| Description | The CHD-APAH patients were more breathless with lower 6-minute walk distance (360 m versus 558 m versus 622 m, P=0.00001). |
| Biomarker | NA |
| Classification | C3 (lifestycle factor - exercise habit) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | The CHD-APAH patients were more breathless with lower 6-minute walk distance |
| p Value | 0.00001 |
| Conclusion | Raised biomarkers for inflammation were found in CHD-APAH. Significant abnormalities in airway physiology may contribute to the dyspnea but are not driven by inflammation as assessed by circulating and sputum cytokines. A relationship between increased serum endothelin-1 and airway dysfunction may relate to its bronchoconstrictive properties. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 466 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/TGA/DILV/TA/TOF/PS/TA/EA |
| Reference | |
|---|---|
| PMID | 29444773 |
| Year | 2018 |
| Title | Lung Function, Inflammation, and Endothelin-1 in Congenital Heart Disease-Associated Pulmonary Arterial Hypertension. |
| Sample | ||
|---|---|---|
| Population | Adults | |
| Source | blood and induced sputum | |
| Region | Bristol, United Kingdom | |
| Method | Spirometry, gas transfer, whole body plethysmography and lung clearance index | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | Surgical Operation | |
| Group | CHD-PAH(Treatment) | CHD without PAH; healthy volunteers(Control) |
| Number | 20 | 20 (CHD without APAH); 18 (Healthy Volunteers) |
| Age | Median age (IQR): 42.7 (33.1–57.7) years | Median age (IQR): 40.0 (32.8–50.6) years (CHD); 31.6 (25.6-38.4) (Healthy Volunteers) |
| Gender (Male: Female) | 8:12 | 10:10 (CHD) 9:9 (Healthy Volunteers) |
| Marker Level | 360.35±123.01 m (CHD-APAH) | 558.82±70.59 m (CHD); 622±80.4 m (Healthy Volunteers) |
