| Factor Information | |
|---|---|
| Data ID | 560 |
| Factor | pro-BNP (pro-brain natriuretic peptid) |
| Description | The mean BNP, pro-BNP, scTnI, and hsTnT levels were statistically significantly higher in patients with PH than in the patients without PH (p < 0.001). |
| Biomarker | YES |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | patients with PH |
| p Value | 0.001 |
| Conclusion | Pulmonary hypertension determined in congenital heart diseases triggers myocardial damage independently of increased volume or pressure load and resistance, occurring by disrupting the perfusion via increasing ventricular wall tension and the myocardial oxygen requirement. Serum scTnI and hscTnT levels may be helpful markers to determine the damage associated with PH in childhood. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 29340731 |
| Year | 2018 |
| Title | Sensitive Cardiac Troponins: Could They Be New Biomarkers in Pediatric Pulmonary Hypertension Due to Congenital Heart Disease? |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | Blood | |
| Region | Ankara, Turkey | |
| Method | Echocardiographic evaluation, invasive hemodynamic investigation, Blood samples were obtained from all cases, for the measurement of brain natriuretic peptide (BNP), pro-brain natriuretic peptide (pro-BNP), sensitive cardiac troponin I (scTnI), and high-sensitive troponin T (hscTnT) levels. | |
| Race | Asian | |
| Disease History | NA | |
| Treatment History | NA | |
| Group | PH group(Treatment) | Non-PH group(Control) |
| Number | 29 | 29 |
| Age | 10.4±8.1 months | 14.1±7.6 months |
| Gender (Male: Female) | 15:14 | 14:15 |
| Marker Level | 1405.6±1935.1 pg/mL | 191.9±266.8 pg/mL |
