| Factor Information | |
|---|---|
| Data ID | 579 |
| Factor | White matter(WM) volumn |
| Description | Children undergoing neonatal cardiopulmonary bypass surgery showed smaller deep GM (Gray matter) (p=0.005) and WM (white matter) (p=0.021) volumes. |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | smaller WM volumes. |
| p Value | 0.021 |
| Conclusion | Brain volumes of children with SV CHD prior to the Fontan completion are smaller compared to controls. Those undergoing CPB surgery during the neonatal period had reduced deep GM and WM volumes. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 119 |
| CHD Type | isolated CHD |
| CHD Subtype | SV |
| Reference | |
|---|---|
| PMID | 29278641 |
| Year | 2018 |
| Title | Reduction of brain volumes after neonatal cardiopulmonary bypass surgery in single-ventricle congenital heart disease prior to Fontan completion. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | brain | |
| Region | Giessen, Germany; Zurich, Switzerland | |
| Method | Volumetric segmentation of cerebral MRI scans, Bayley-III scales. | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | neonatal cardiopulmonary bypass surgery | |
| Group | Children with neonatal CPB(Treatment) | Children without neonatal CPB(Control) |
| Number | 44 | 8 |
| Age | 26.7 ± 3.9 months | 29.8 ± 9.5 months |
| Gender (Male: Female) | 28:16 | N/A |
| Marker Level | 225.5 ± 21.3 mL | 283.5 ± 28.8 mL |
