| Factor Information | |
|---|---|
| Data ID | 582 |
| Factor | White matter(WM) volumn |
| Description | Brain volumes were smaller in patients compared to controls (GM: p=0.017, deep GM: p=0.012, WM: p=0.015), whereas CSF volumes were greater (p=0.014). |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | WM volumn were smaller |
| p Value | 0.015 |
| Conclusion | Altered brain volumes may result from diffuse microstructural brain injury, underscoring the importance of volumetric measurements as a sensitive tool for the assessment of brain development. Assessments of our patient’s neurodevelopmental performance at school age will determine the long-term clinical impact of these early imaging findings. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 119 |
| CHD Type | isolated CHD |
| CHD Subtype | SV |
| Reference | |
|---|---|
| PMID | 29278641 |
| Year | 2018 |
| Title | Reduction of brain volumes after neonatal cardiopulmonary bypass surgery in single-ventricle congenital heart disease prior to Fontan completion. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | brain | |
| Region | Giessen, Germany; Zurich, Switzerland | |
| Method | Volumetric segmentation of cerebral MRI scans, Bayley-III scales. | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | neonatal cardiopulmonary bypass surgery | |
| Group | CHD of SV(Treatment) | Control(Control) |
| Number | 44 | 8 |
| Age | 26.7 ± 3.9 months | 29.8 ± 9.5 months |
| Gender (Male: Female) | 28:16 | N/A |
| Marker Level | WM: 277.1 ± 29.6 mL | WM: 330.9 ± 64.2 mL |
