| Factor Information | |
|---|---|
| Data ID | 584 |
| Factor | CSF/ICV(intracranial volume) |
| Description | Of all intracranial volumes, only CSF volume was associated with neurodevelopmental outcome, accounting for 21% (p=0.011) of variability in the cognitive composite score when combined with common risk factors in a multivariable analysis. |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | neurodevelopmental outcome |
| p Value | 0.001 |
| Conclusion | Increased CSF volume represents a significant risk factor for neurodevelopmental impairment in children with single ventricle CHD. Later assessments are warranted to determine the prognostic role of intracranial volumes for long-term outcome. |
| Risk Factor | risk factor (article mentioned) |
| CHD Type | |
|---|---|
| ID | 119 |
| CHD Type | isolated CHD |
| CHD Subtype | SV |
| Reference | |
|---|---|
| PMID | 29278641 |
| Year | 2018 |
| Title | Reduction of brain volumes after neonatal cardiopulmonary bypass surgery in single-ventricle congenital heart disease prior to Fontan completion. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | brain | |
| Region | Giessen, Germany; Zurich, Switzerland | |
| Method | Volumetric segmentation of cerebral MRI scans, Bayley-III scales. | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | neonatal cardiopulmonary bypass surgery | |
| Group | CHD of SV(Treatment) | Control(Control) |
| Number | 44 | 8 |
| Age | 26.7 ± 3.9 months | 29.8 ± 9.5 months |
| Gender (Male: Female) | 28:16 | N/A |
| Marker Level | 0.017 (0.013, 0.024) | 0.011 (0.009, 0.014) |
