| Factor Information | |
|---|---|
| Data ID | 586 |
| Factor | plasma glucose |
| Description | In a sensitivity analysis excluding women with a pre-existing diagnosis of diabetes , the positive association between a random plasma glucose value with risk for congenital heart disease among offspring was essentially unchanged (aOR 1.09, 95% CI 1.02-1.14, P = .003) |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | congenital heart disease in offspring |
| p Value | 0.003 |
| OR | 1.086 |
| Conclusion | Our observations demonstrate that higher random plasma glucose values measured during early pregnancy correlate with increased risk for congenital heart disease in offspring of mothers who do not have diabetes. Furthermore, plasma glucose measured during early pregnancy was more associated with risk for congenital heart disease in offspring, compared with the OGTT which is often used to risk-stratify pregnancies for fetal-echocardiographic screening. |
| Risk Factor | no influencing factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 29254757 |
| Year | 2018 |
| Title | First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. |
| Sample | ||
|---|---|---|
| Population | Offspring of mother | |
| Source | maternal serum | |
| Region | Stanford, United States; Danville, United States | |
| Method | retrospective multi-institutional cohort | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | excluding mother-infant dyads with pre-exising maternal DM(Treatment) | N/A(Control) |
| Number | 2204 | N/A |
| Age | N/A | N/A |
| Gender (Male: Female) | 0:2204 | N/A |
| Marker Level | N/A(excluding mother-infant dyads with pre-exising maternal DM) | N/A |
