| Factor Information | |
|---|---|
| Data ID | 591 |
| Factor | parental periconceptional exposure |
| Description | N/A |
| Biomarker | NA |
| Classification | B3 (environmental factor - exposure history) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | children with CHD |
| p Value | 0.001 |
| Conclusion | Parental periconceptional exposure was significantly higher in CHD cases with respect to control newborns. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 471 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/TOF/AVSD/DORV/TGA |
| Reference | |
|---|---|
| PMID | 29185192 |
| Year | 2018 |
| Title | A Functional Aryl Hydrocarbon Receptor Genetic Variant, Alone and in Combination with Parental Exposure, is a Risk Factor for Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | questionnaires | |
| Region | Italy, Pisa | |
| Method | T-test | |
| Race | European | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | mother of CHD patient/ father of CHD patient(Treatment) | mother of control/ father of control(Control) |
| Number | 49(mother of CHD patient), 65(father of CHD patient) | 62(mother of control), 94(father of control) |
| Age | 6.2±6.7 years | at birth |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 38.3%(mother of CHD patient), 50.8%(father of CHD patient) | 22.6%(mother of control), 34.3%(father of control) |
