| Factor Information | |
|---|---|
| Data ID | 595 |
| Factor | AhR p.Arg554Lys-Dominant(Lys/Lys and Arg/Lys vs.Arg/Arg) |
| Description | N/A |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | children with CHD |
| p Value | <0.0001 |
| OR | 2.9 |
| Conclusion | A significant elevated CHD risk was found under materal dominant model. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 471 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/TOF/AVSD/DORV/TGA |
| Reference | |
|---|---|
| PMID | 29185192 |
| Year | 2018 |
| Title | A Functional Aryl Hydrocarbon Receptor Genetic Variant, Alone and in Combination with Parental Exposure, is a Risk Factor for Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | blood | |
| Region | Italy, Pisa | |
| Method | Real time-PCR | |
| Race | European | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD patient(Treatment) | control(Control) |
| Number | 128 | 274 |
| Age | 6.2±6.7 years | at birth |
| Gender (Male: Female) | 76:52(total) | 160:114(total) |
| Marker Level | Lys/Lys and Arg/Lys vs.Arg/Arg(10 and 50: 68) | Lys/Lys and Arg/Lys vs.Arg/Arg(5 and 58: 211) |
