| Factor Information | |
|---|---|
| Data ID | 597 |
| Factor | maternal exposure combined with Arg/Arg |
| Description | N/A |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | Interaction analysis between the AhR polymorphism and maternal exposures)children with CHD |
| p Value | 0.1 |
| OR | 1.6 |
| Conclusion | Regarding paternal influence, the simultaneous presence of risk allele and smoking habit lead to almost fivefold increased risk to CHD (ORsmoking = 1.6, 95% CI = 0.9–2.9; ORallele = 2.6, 95% CI = 1.3–5; ORinteraction = 4.9, 95% CI = 2.4–9.9) |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 471 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/TOF/AVSD/DORV/TGA |
| Reference | |
|---|---|
| PMID | 29185192 |
| Year | 2018 |
| Title | A Functional Aryl Hydrocarbon Receptor Genetic Variant, Alone and in Combination with Parental Exposure, is a Risk Factor for Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | questionnaires | |
| Region | Italy, Pisa | |
| Method | T-test and unconditional logistic regression analysis;Real time-PCR | |
| Race | European | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD patient(Treatment) | control(Control) |
| Number | 23 | 47 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 23(18%) | 47(17.2%) |
