| Factor Information | |
|---|---|
| Data ID | 7 |
| Factor | hsa_circRNA_079265 |
| Description | Circular RNAs are a large class of non‐coding RNAs that exist ubiquitously in the cytoplasm of eukaryotic cells.These endogenous RNAs are characterized by a stable structure and exhibit tissue‐specific expression patterns |
| Biomarker | YES |
| Classification | D4 (molecular factor - RNA) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To access novel diagnostic biomarkers for congenital heart disease in children |
| p Value | <0.05 |
| Conclusion | We identified three circRNAs that were significantly under‐expressed in children with CHD compared with healthy ones. The validation results agreed with the ROC curves |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 38 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD |
| Reference | |
|---|---|
| PMID | 31429492 |
| Year | 2019 |
| Title | Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | plasma | |
| Region | Nanjing, China | |
| Method | Gene ontology (GO), pathway, and network analysis were performed to predict a network of circRNA/miRNA and target mRNAs related to CHD. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | VSD/ASD(Treatment) | healthy children(Control) |
| Number | 40 | 40 |
| Age | N/A | matched with cases on the basis of age and gender |
| Gender (Male: Female) | F/M | F/M |
| Marker Level | 4.23 ± 2.59 | 2.09 ± 1.37 |
