| Factor Information | |
|---|---|
| Data ID | 872 |
| Factor | IQR using dummy variables for CHD subgroups--IQR vs. Motor |
| Description | We assessed associations between fetal heart rate parameters including interquartile range and s.d. of the fetal RR intervals and 18-month Bayley Scales of Infant Development-III scores using Pearson’s correlation coefficient. |
| Biomarker | NA |
| Classification | F6 (psychosocial factor - other) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | We aimed to explore the correlation between fetal autonomic activity, measured by fetal heart rate variability, and 18-month developmental outcome in subjects with congenital heart disease. |
| p Value | 0.001 |
| Conclusion | In fetuses with congenital heart disease, low heart rate variability at 34 to 38 weeks gestational age predicts diminished 18-month Cognitive and Motor performance. Prenatal autonomic activity may serve as a marker of early childhood development in these high-risk patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 499 |
| CHD Type | isolated CHD |
| CHD Subtype | HLHS/TOF/TGA |
| Reference | |
|---|---|
| PMID | 28471442 |
| Year | 2017 |
| Title | An antenatal marker of neurodevelopmental outcomes in infants with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | fetuses | |
| Source | prospective observational cohort study | |
| Region | New York, USA | |
| Method | reviewed | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | 23 fetuses (5 HLHS, 9 d-TGA and 9 TOF)(Treatment) | N/A(Control) |
| Number | 23 | N/A |
| Age | 36.3 weeks (range 34 to 38.7) | N/A |
| Gender (Male: Female) | 12:11 | N/A |
| Marker Level | N/A | N/A |
