| Factor Information | |
|---|---|
| Data ID | 969 |
| Factor | GIT symptoms--Age at onset of symptoms (<6 month) (percent) |
| Description | Univariate analysis between GIT symptoms and serum antigliadin IgG antibodies levels in the studied patients |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | This study was designed to evaluate age-dependent serum levels of antigliadin antibodies among malnourished Egyptian infants with CHD and gastrointestinal symptoms. |
| p Value | 0.04 |
| OR | 5.69 |
| Conclusion | On analysing risk factors using odds ratio, the age at onset of GIT symptoms, diarrhoea, abdominal pain, and distension had been found to be significantly associated with high serum antigliadin antibodies among malnourished CHD infants with a prediction of 95%. Serum IgA, IgM, and IgG class antibodies to gliadin play a significant role in the pathogenesis of malnutrition in infants with CHD. Gluten containing foods should never be introduced before the end of the six months. |
| Risk Factor | risk factor(article mentioned) |
| CHD Type | |
|---|---|
| ID | 494 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TOF/TGA/PA, VSD/DORV, MGV/ASD |
| Reference | |
|---|---|
| PMID | 28293318 |
| Year | 2017 |
| Title | Gluten Sensitivity among Egyptian Infants with Congenital Heart Disease. |
| Sample | ||
|---|---|---|
| Population | infants | |
| Source | case-control study | |
| Region | Giza, Egypt | |
| Method | This case-control study conducted on 60 infants with established congenital heart disease. Serum antigliadin antibodies levels were measured using ELISA. | |
| Race | Africa | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Total Patients (IgG levels high)(Treatment) | Total Patients (IgG levels Normal)(Control) |
| Number | 5(total:12) | 14(total:48) |
| Age | 4-12 months (mean 8.72 ± 6.68 months) | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 16 (38.1%) | 14 (77.8%) |
