| Factor Information | |
|---|---|
| Data ID | 989 |
| Factor | NT-proBNP--Time points (12 h after surgery) |
| Description | Results for the joint modeling analysis of a linear mixed effects model for NT-proBNP from before to 36 hours after surgery and a generalized linear model for the duration of the mechanical ventilation. |
| Biomarker | YES |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | prognosis and risk assessment |
| Objective | To assess the relationship between N-terminal pro–brain natriuretic peptide (NT-proBNP) levels at different time points and early outcome, and to evaluate the reliability of NT-proBNP level as a predictor of early outcome after surgery in a large series of children with congenital heart disease (CHD). |
| p Value | <0.0001 |
| Conclusion | The results for the longitudinal submodel were consistent with the results from the separate LME analysis. The differences in magnitudes of the parameter estimates were negligible and there was no material difference in terms of statistical significance. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 495 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/TAPVR/TOF/TGA/PA/ASD/CoA/DORV/IAA/PS/other |
| Reference | |
|---|---|
| PMID | 28283228 |
| Year | 2017 |
| Title | Perioperative NT-proBNP level: Potential prognostic markers in children undergoing congenital heart disease surgery. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | Blood | |
| Region | Guangzhou,China | |
| Method | A retrospective observational study involving 363 consecutive children with CHD was used. Plasma NT-proBNP records were obtained for each patient before and 1, 12, and 36 hours after surgery. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | cardiac surgery | |
| Group | total CHD (12 h after surgery)(Treatment) | total CHD (36 h after surgery)(Control) |
| Number | 363 | 363 |
| Age | 15.8 ± 27.4 months | 15.8 ± 27.4 months |
| Gender (Male: Female) | 235:128 (total) | 235:128 (total) |
| Marker Level | Estimate(95% CI)=0.37 (0.21 to 0.53) RE%: 44.77 | Reference: N/A |
